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»ISBN: 0896037363
»Book author: James Gray, Ulrich Desselberger

Book Description:
Addenbrooke’s Hospital, Cambridge, UK. Collection of established methods for studying the structure, molecular biology, pathogenesis, epidemiology, and prevention in animal models of infection with rotaviruses, a cause of infant morbidity and mortality. Expanded-outline format. DNLM: Rotavirus Laboratory Manuals.

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Regulation of Sertoli Cell and Germ Cell Differentiation (Advances in Anatomy, Embryology and Cell Biology)

Product Details
»Book Publisher: Springer (26 October, 2005)
»ISBN: 3540257500
»Book author: R. Brehm, K. Steger

Book Description:
Unwanted childlessness affects approximately one in six couples worldwide. Although the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization, in nearly 40 % of cases the cause can be attributed to the female, in 20 % to the male, in 25 % to both, and in 15 % the cause remains unknown. Based on these figures, the incidence of male factor infertility in the general population is approximately 7 %. The majority of these men, approximately 30 %, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression and tumour progression may be favoured by an aberrant Sertoli cell germ cell communication. The intention of the present monograph is to shed more light on the regulation of Sertoli cell and germ cell differentiation. Involving knockout and transgenic mouse models, the authors focus on male factor infertility that might be related to altered maturation of Sertoli cells, male factor infertility that might be due to incorrect histone-to-protamine exchange in haploid spermatids, and progression of testicular germ cell cancer that might be favoured by an aberrant Sertoli cell germ cell communication.

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Product Details
Book Publisher: Cold Spring Harbor Laboratory Press (01 February, 2001)
ISBN: 0879695757
Book author: Daniel R. Marshak, Richard L. Gardner, David Gottlieb

Book Description:
Stem cells are the focus of intense interest from a growing, multidisciplinary community of investigators with new tools for isolating and characterizing these elusive cell types. This volume, which features contributions from many of the world’s leading laboratories, provides a uniquely broad and authoritative basis for understanding the biology of stem cells and the current excitement about their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their collaborators in the emerging field of regenerative medicine.

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* Publisher: Informa Healthcare
* Number Of Pages: 536
* Publication Date: 1996-06-07
* ISBN-10 / ASIN: 0824797027
* ISBN-13 / EAN: 9780824797027
* Binding: Hardcover

Product Description:
This unique reference integrates the theory and practical use of aerosols in inhalation therapy into a single resource-presenting the physical chemistry of formulation, the physics of aerosol generation, aerodynamic behavior, and therapeutic implications. Offers up-to-date techniques for droplet and particle generation, including air-blast and ultrasonic nebulizers, propellant-driven metered-dose inhalers, dry-powder inhalers, and elecctrospray systems!

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* Publisher: Elsevier Science
* Number Of Pages: 352
* Publication Date: 2008-08-12
* ISBN-10 / ASIN: 0444532749
* ISBN-13 / EAN: 9780444532749
* Binding: Hardcover

Product Description:
Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. Toxicogenomics is important because it may enhance understanding of mechanisms of toxicity, cellular defence systems, and drug action. If this technique is proven to work, it could be used in a similar way for toxicology and toxin-determination to DNA-testing in the forensic identification of individuals.

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Publisher: S. Karger Publishers (USA)
Number Of Pages: 148
Publication Date: 1998-01
ISBN-10 / ASIN: 3805565674
ISBN-13 / EAN: 9783805565677
Binding: Hardcover

Product Description:
In recent years, gap junction research in the cardiovascular system has considerably improved the understanding of cardiac function and the vasculature in health and disease. The present book focuses on the communication of intercellular gap junctions in the cardiovascular system but also includes aspects of physiology, medicine and cell biology.

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* Publisher: Elsevier Science
* Number Of Pages: 368
* Publication Date: 1996-12-01
* ISBN-10 / ASIN: 0762301465
* ISBN-13 / EAN: 9780762301461
* Binding: Hardcover

Product Description:
The present volume is the first in the advances in oncobiology series. It is meant to be useful not only to clinical and non-clinical oncologists but also to graduate students and medical students. The individual chapters are presented as self-contained summaries of current knowledge rather than as reviews. The last chapter deals with the subject of chemotherapy.

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* Publisher: Cambridge University Press
* Number Of Pages: 284
* Publication Date: 2008-11-10
* ISBN-10 / ASIN: 0521867177
* ISBN-13 / EAN: 9780521867177
* Binding: Hardcover

Product Description:
Peripheral nerve disorders are among the most common neurological problems that clinicians face, yet few therapies and interventions are available to arrest or reverse the damage associated with them. Summarizing this important, but neglected, area of neuroscience, Doug Zochodne addresses the peripheral nervous system and its unique neurobiology. He summarises current basic ideas about the molecular mechanisms involved in both nerve degeneration and regeneration and what approaches can be used to address it experimentally.

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* Publisher: Humana Press
* Number Of Pages: 458
* Publication Date: 2008-11-18
* ISBN-10 / ASIN: 1588298590
* ISBN-13 / EAN: 9781588298591
* Binding: Hardcover

Product Description:
Despite major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition", expert researchers provide clear, state-of-the-art methods for the study of HIV.

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Publisher: Humana Press
Number Of Pages: 768
Publication Date: 2005-04-15
ISBN / ASIN: 1588294250
EAN: 9781588294258

Book Description:
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

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Publisher: Wiley-VCH
Number Of Pages: 9600
Publication Date: 2006-01-03
ISBN-10 / ASIN: 3527305424
ISBN-13 / EAN: 9783527305421
Binding: Hardcover

Product Description:
This second edition of the Encyclopedia of Molecular Cell Biology and Molecular Medicine covers the molecular and cellular basis of life, disease, and therapy at university and professional researcher level. With its 16 volumes, this is the most comprehensive and detailed treatment of molecular cell biology and molecular medicine available today.

part 1 / part 2 / part 3